GENETIC VARIABILITY OF THE CKM GENE AND SPORTS PERFORMANCE

Oral Presentation

Abstract

DOI: https://doi.org/10.30472/aesa-conf.v7i1

Background: Weightlifting athletes use the phosphagen pathway in which the enzyme creatine kinase (CKM) participates, which is translated from the CKM gene, it participates in the energy supply of the muscle because it catalyzes the reversible transfer of (CK PCr) to (ADP), generating (ATP). Aim: To identify the frequency of polymorphisms in the CKM gene associated with sports performance in a group of high-performance athletes from the Weightlifting League of Valle del Cauca. Methods: Cross-sectional descriptive observational study in which the presence of genetic variants present in the CKM gene was determined in 25 elite athletes assigned to the Weightlifting League of Valle del Cauca. Results: The rs17875653 variant is a single nucleotide variation where a G>C is changed and produces a change in the amino acid sequence of the protein that does not modify the function of the protein, but modifies the hydrogen bonds in the protein. protein structure. Conclusion: This study shows that the rs17875653 variant is associated with sporting achievements, therefore, an adequate training plan can be generated to enhance the development of strength in high-performance Olympic weightlifting athletes of the Valley League. del Cauca and contribute to the processes of talent selection and sports improvement.